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Alstonine, Flavopereirine, Sempervirine, Serpentine, Pao Pereira, Rauwolfia, Ginko biloba & the Work of Mirko Beljanski

Alstonine, Flavopereirine, Sempervirine, Serpentine, Pao Pereira, Rauwolfia, Ginko biloba & the Work of Mirko Beljanski

For 40 years, the Yugoslavian molecular biologist, Mirko Beljanski PhD (1923–1998), in association with his wife and research associate, Monique, conducted research into the respective roles of DNA and RNA in the development and cure of cancer, first at the Pasteur Institute in France (1948–1978) and then at the Faculty of Pharmacy at Chatenay Malabry (1978–1988). During this time, he wrote 133 papers, published in both French and international journals.

Cancer is generally regarded as arising from damage to or mutations of the molecular structure of DNA. Beljanski’s primary thesis is that cancer is caused not only by DNA mutations but also by damage to the hydrogen bonds that hold the two strands of the DNA double helix together. Like a damaged zipper than is failing in places, allowing the two parts to separate, cancerous or pre-cancerous DNA has many broken or weakened hydrogen bonds. Once these bonds are broken over a particular area of the double helix, the DNA in that area is destabilized, and carcinogens are more readily able to infiltrate and cause the molecular damage that can lead to cancer. This explains, for example, why an excess of certain hormones such as estrogen and testosterone (and other steroids, too) is carcinogenic, although they do not appear to be the direct cause of mutations.

Among his other discoveries is that fragments of RNA (which he called Beljanski Leucocyte Restorers or BLBs) are capable of rapidly restoring the depletion of (red) blood platelets and (white) leucocytes brought about by radiation therapy and chemotherapy agents. BLBs selectively stimulate the normal replication of red and white blood cells in the bone marrow and spleen, without enhancing the proliferation of cancer cells. Beljanski reported that patients who received BLBs along with chemotherapy suffered few of the expected side effects, such as nausea and hair loss, and were able to continue with their normal daily lives.

Beljanski also developed what he called the ‘contest’ – a way of determining which kind of substances could destabilize DNA function, leading to cancerous cell proliferation, and, conversely, which kind of substances could repair or cause the programmed death (apoptosis) of damaged and cancer-forming DNA. Among such molecules, he discovered, are the naturally occurring plant alkaloids, also nine, flavopereirine, serpentine and sempervirine, which are able to distinguish between normal and cancer-forming DNA, either repairing the damaged DNA or causing the death of the malignant cells (apoptosis). Beljanski conducted many trials on the anti-cancer properties of these substances. He was able, for example, to cure an appreciable proportion of mice with lymphoma. Other in vitro studies showed that flavopereirine was active against a number of other cancer cell lines (brain, breast, ovarian, prostate, kidney, thyroid, pancreatic, colon, liver, skin), including those that were multidrug-resistant.

His research also showed that the flavanone, JO-1, which contains a large amount of naringin as well as some as yet unidentified substances, prevented the multiplication (in vitro) of human cancer cell lines (colon, ovary, breast, leukemia). Under the same experimental conditions, normal bone marrow cell multiplication was not affected. He also demonstrated that these substances also work in synergy with standard chemotherapy agents, providing better results than with the chemotherapy alone.

Dr Beljanski was forced to leave the Pasteur Institute when his innovative ideas came into conflict with the Institute’s new director. Underfunded, he continued his research and the publication of scientific papers, mostly in French. His wife, Monique, and daughter, Sylvia, now endeavor to bring the fruits of his research to a wider public. Sylvia Beljanski is president of Natural Source International Inc., in New York, the US company that now manufactures the Beljanski products.

Although he worked informally with many doctors in France and Belgium, Beljanski was largely ostracized by French oncologists. For a number of years prior to his death in 1998, he was persecuted as a charlatan, despite the commendations of many users of his products, including the French president, François Mitterand. In one instance, a journalist who had set out to expose Beljanski was not only unable to find any evidence of fraud, but ultimately became a grateful user of his products when he discovered that he himself had intestinal cancer. Beljanski’s work is the subject of a book, The Beljanski Anti-Cancer Remedies: Inside the Double Helix of DNA (2006).

The Beljanski products are now manufactured in the USA according to Beljanski’s methods. They have been shown to be totally non-toxic to animals and humans in the recommended doses:

Pao VAn extract of the bark of the Amazonian tree, Pao Pereira (Geissospermum vellosii), contains the alkaloid flavopereirine (also called PB-100). Flavopereirine is a smaller molecule than also nine, and is able to cross the blood-brain barrier, making it useful in the treatment of brain tumors. Research studies, many being in vitro, have shown flavopereirine to be effective
Medicinal Mushrooms

Medicinal Mushrooms

A number of mushrooms and fungi have been shown in various studies to contain substances (mostly complex polysaccharides) that stimulate the body’s immune system (particularly its T-cell lymphocytes, macrophages, and natural killer cells) to destroy cancer cells, lessen the side effects of chemotherapy and radiation therapy, and combat viral infections. In some instances, tumors have been entirely eliminated. Most of these mushrooms have long been used in traditional Chinese medicine, dating back to at least 100 AD, and have been eaten as food for thousands of years in the East. Among the world’s edible mushrooms, shiitake are second in popularity only to the common button mushroom (Agaricus bisporus).

Six species are of particular interest: reishi (Ganoderma lucidum), shiitake (Lentinula edodes), maitake (Grifola frondosa),Cordyceps sinensis,Trametes or Coriolus versicolor, and Agaricus blazei muril (ABM). The latter originated in Brazil, but has been cultivated in Japan since 1965, where it is known as Himematsutake. Since at least the 1960s, a considerable amount of scientific research has been and is being conducted (especially in Japan and China) into the anti-cancer substances found in these six mushrooms.

Medicinal mushrooms are available commercially as dried powdered whole mushrooms, as a dried extract, or as a liquid extract. Depending upon your local climate, it may also be possible to grow them for yourself. Extracts can be made in warm water over a period of 2-6 hours, or in hot water over a shorter period. A few manufacturers first use hot water, and then alcohol, to maximize the volume and variety of substances extracted. Products can be made from the mycelium and/or from the fruiting body, between which there is a difference in the level of active anti-cancer substances. Which extraction method is best is currently difficult to determine, especially in the absence of data from laboratory trials. The best method of extraction may even vary from one mushroom to another. Growing methods can also result in considerable variations in the quantity of the active substances present. But again – despite all the assertions of manufacturers and other ‘experts’ – there is minimal published data on which to base any decision. Having reviewed the literature (often in confusion!), I suspect that extracts using both water and alcohol are probably best. This is also the form used by both Dr Julian Kenyon of the Dove Clinic in the UK and Dr Etienne Callebout of Harley Street, London.

I guess that until there is standardization and each manufacturer measures and publishes the levels of active ingredients in their products (an expensive procedure), there will always be uncertainty over quality. Presently, many manufacturers actually play on this uncertainty when promoting their own particular brands, something that they could eliminate by publishing the relevant data. And until there are full-scale clinical trials, the dosage will remain a matter of informed guesswork. Personally, I am using the extracts from mushrooms grown and processed by Fruiting Bodies, at their place in Wales.

A number of extracts of the active compounds found in shiitake mushrooms are sold as proprietary products. These include lentinan (shown in trials to stop or slow tumor growth) and eritadenine (thought to help in the reduction of blood clots and to lower cholesterol by blocking the way cholesterol is absorbed into the bloodstream). Another product – active hexose correlated compound (AHCC) – a proprietary extract prepared from several species of medicinal mushroom, including shiitake, is claimed to effectively inhibit tumor growth and lessen the side effects of chemotherapy. However, full details of the mushroom species used and the method of preparation are not disclosed by the producers, and most of their claims relate to the properties of medicinal mushrooms in general, rather than AHCC in particular.

Other proprietary mushroom compounds, including grifolan (from maitake), schizophyllan (from Schizophyllum commune), and SSG (from Sclerotinia sclerotiorum), are available in Japan, where lentinan and schizophyllan have been approved as anti-cancer drugs. It is worth noting that many of the animal and human clinical studies of lentinan have been made using an injected form. The efficacy of lentinan when taken orally remains uncertain.

Occasional side effects seem to be restricted to diarrhea and bloating, which generally go away after a few days. Allergic responses affecting the skin, nose, throat, or lungs have also been reported by some people.

Note that Agaricus blaze contains a small number of carcinogenic agaritines, which are metabolized by the body into highly carcinogenic derivatives. These can be removed from A. blazeii extracts by specialized processing without adversely affecting its medicinal properties, but not all manufacturers take this step. So before using A. blazeii, it is worth getting clear feedback from the producers concerning the level of agaritines in their A. blazeii products. Incidentally, the commonly consumed button mushroom (A. bisporus) and others of the family (e.g. …

Hydrazine Sulphate

Hydrazine Sulphate

Hydrazine sulfate (or sulfate, in US spelling) is a commonly used, inexpensive industrial compound. Biologically, it inhibits a particular liver and kidney enzyme (a monoamine oxidase or MAO), thereby preventing cancer cells from obtaining glucose. This has been shown to inhibit cachexia (wasting), which is the immediate cause of death in over 70% of cancer cases. In a smaller number of cases, there is also some tumor regression. This enables some patients to overcome their cancer or live with it. This has been demonstrated in several clinical trials.

Research began in 1968 with an article suggesting that cachexia could be reduced by targeting a particular liver and kidney enzyme. Dr Joseph Gold of the Syracuse Cancer Research Institute of New York, who has pioneered the use of hydrazine sulfate as a cancer treatment, began testing rodents with hydrazine sulfate, getting rapid and positive results. The compound was then tested on human beings, with mixed results.

Like most cancer treatments, mainstream or complementary, hydrazine sulfate does not always work. There is also a long list of foods with which it interacts badly, and it should only be taken under medical supervision. Like other MAO inhibitors, it is incompatible with barbiturates, tranquilizers, alcohol, and other depressants of the central nervous system. Foods high in the amino acid, tyramine, such as mature cheeses and fermented foods should also be avoided.

Hydrazine sulfate has been the focus of considerable controversy in the cancer industry. Mainstream organizations refer to trials sponsored by the National Cancer Institute in the mid-1990s, which showed no benefit from its use. Critics have observed that these trials did not follow the correct procedures, since 94% of the patients were given tranquilizers, and were permitted the use of alcohol and barbiturates.

Annie Appleseed Project – An excellent introduction and overview, with some details of dosage, and which foods to avoid.

Diagnose Me – A useful overview.

Day Industries – Hydrazine Sulfate: The Real Story. A narrative overview.

Syracuse Cancer Research Institute – The charitable organization where Dr Joseph Gold works.

The Truth about Hydrazine Sulfate – Dr Joseph Gold tells his side of the story.

National Cancer Institute – A summary of hydrazine sulphate trials and other information from the viewpoint of the NCI.

National Institute of Health – A summary of the events in the political and trial history of hydrazine sulphate.

The Moss Reports – A review of trial data from before the publication of results from the NCI-sponsored trials.

Dr Burton Goldberg – “Holding the National Cancer Institute Accountable for Cancer Deaths.” An overview of some of the politics surrounding hydrazine sulphate.

Nu-gen Nutrition – A source of hydrazine sulphate from a US supplier of complementary cancer treatments.

Caesium Chloride– High pH Therapy

Caesium or cesium (US spelling) chloride is associated with the high pH (alkalinizing) therapeutic approach to cancer treatment. The theory that cancer cells are more susceptible than normal cells to high pH originated with the observation that certain areas of the world with a lower risk of cancer also had a higher soil concentration of alkali metals (especially potassium, cesium, and rubidium).

Researchers back in the 1920s first suggested cesium might be a useful anti-tumor agent. However, further studies in the 1930s showed no evidence for this. The high pH therapy for cancer was first advanced during the 1980s by Keith Brewer PhD, who published numerous papers and articles concerning the treatment, together with suggestions for further research. Dr Brewer was a physicist who felt that many of the findings of physics were relevant to biology, especially the physics of the cell membrane. He arrived at his therapeutic approach after considerable experimentation on cell membranes. Animal research studies confirming his theory, funded by Dr Brewer, were undertaken by Dr Marilyn Tufte of the Department of Biology at the University of Wisconsin at Platteville. A small number of uncontrolled human trials conducted by various physicians, especially Dr H.A. Nieper in Hannover, Germany, and Dr H.E. Sartori in Washington, DC, also showed significant positive results. As well as loss of pain within 12 to 24 hours, the treatment also resulted in rapid shrinkage of the tumor mass. However, Nieper and Sartori were also using vitamin B17, which in itself is regarded as a significant cancer treatment, so their results are not conclusive.

High pH therapy using caesium chloride therapy is usually given to patients with advanced metastatic cancer, for whom standard medicine can do no more. However, due to lack of sufficient research, there is no agreed dosage or treatment protocol. Generally, up to 6 to 9 gms per day (or sometimes more) of caesium chloride is administered in liquid form along with vitamins A and C, together with zinc and selenium supplements, which enhance the cellular uptake of caesium. Keith Brewer observes that there is some evidence …

Lycopene, Zinc, Pumpkin Seeds, Prostatol, Prostate Care, etc.

Lycopene, Zinc, Pumpkin Seeds, Prostatol, Prostate Care, etc.

As manufacturers and vendors of nutritional products are quick to point out, benign prostatic hypertrophy (BPH) or enlargement is common in men over 50, and prostate cancer is one of the commonest cancers. Addressing this market and making use of traditional herbal knowledge as well as research into herbal phytochemicals, vitamin and supplement manufacturers have come up with a range of products designed to promote prostate health. Though the ingredients may have been subject to various scientific studies, no clinical trials have been conducted into the relative efficacy of these products, and it is not thought that they can fight existing cancers on their own. They are of more use in the general maintenance of prostate health.

The many ingredients used in the various products include tomato extract (contains the antioxidant and anti-cancer agent, lycopene); licorice extract (anti-inflammatory); cranberries (protect against urinary tract infections, with a number of other benefits); pumpkin seeds (contain anti-inflammatory sterols; also a diuretic, helping urinary flow; also high in zinc, present naturally at high levels in the prostate); the essential amino acids, glutamic acid, alanine, and glycine (reduce the symptoms of BPH); zinc gluconate (reduces symptoms of BPH); selenium (a powerful antioxidant, with anti-cancer properties); pygeum (maintains healthy cholesterol levels, elevated cholesterol levels being associated with BPH); saw palmetto (relieves the symptoms of BPH, when combined with pygeum); nettle (promotes prostate health); marshmallow (promotes urinary flow and has soothing properties); and other herbs. Internet searches on the above will yield many results. Only a few such links are given below.

Among the many proprietary supplements being marketed are Prostatol, Prostate Care, Prost 8 Palmetto, Dim Palmeto Prostate, Prosta-Vita, and others. There seems to be no data that enables a person to determine which are the most effective.

It is worth noting that epidemiological (population) studies on those who consume significantly larger quantities of tomatoes and tomato-based products have a lower risk of prostate cancer. Moreover, because of the heat applied during the manufacturing process, the lycopene in concentrated tomato products is more readily absorbed by the body than from fresh tomatoes. Tomato paste (23.3 mums/100gms) and tomato ketchup (17 mums/100gms) are the best sources and have a far higher lycopene content than fresh tomatoes (3 mums/100gms). Lycopene is a fat-soluble carotenoid, and there is evidence that tomatoes taken in association with oil are absorbed far better into the body. Studies on rats have indicated that lycopene appears to act in synergy with other compounds in tomatoes. This implies that supplements containing lycopene alone may not be as effective as whole tomato products.

Science Daily – “Lycopene’s Anti-cancer Effect Linked to Other Tomato Components.” A readable report (2003) of the various studies.

Journal of the National Institute of Cancer – The scientific study suggests that whole tomato are far better than lycopene alone in preventing prostate cancer.

The Cancer Project – How lycopene protects against cancer.

“Lycopene” – Wikipedia – An assessment of the research.

“Lycopene” – American Cancer Society – An assessment of the research.

The World’s Healthiest Foods – On the health benefits of cranberries.

Cornell University – “Selenium supplements can reduce cancer rates.”

Innate Response – Manufacturer of Prostate Response.

Santa Monica Homeopathic Pharmacy – A US vendor of Prostatol, Prost 8 Palmetto, Dim Palmetto Prostate, Prosta-Vita, and other prostate formulae.

Vitacost – A US vendor of high concentration Natrol lycopene from tomato extract.

Zinc

Zinc is a naturally occurring element, involved in a number of bodily biochemical functions. It is found in legumes, brewer’s yeast, cashew nuts, pumpkin seeds, dairy products, and whole grains, as well as meat, fish, and poultry. In the cancer scenario, it functions as an immuno-stimulant and an antioxidant, helping to mop up the free radicals that can lead to cancer. Zinc deficiency has also been linked to an increased risk of esophageal squamous cell cancer. Zinc is found in high concentrations in the prostate gland and is present in prostate secretions, where it assists sperm motility. Zinc is also involved in bone formation and the regulation of neural synaptic signaling. It is present in over 300 enzymes.

Zinc supplementation usually comes in the form of zinc gluconate, zinc sulphate, or zinc acetate. It is involved in the acuity of the sense of smell and taste and is used to help treat the loss of taste resulting from head and neck radiation therapy and the disturbances to taste caused by chemotherapy, although the results of studies concerning taste are mixed. Zinc is also an ingredient of supplements designed to help reduce the symptoms of benign prostate enlargement, common in men over 50.

The recommended daily allowance is 11 mg for men and 8 mg for women. Zinc supplements, including multivitamins, normally contain 15 mg, to be taken once a day. Zinc elevates the levels of blood testosterone, …