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Hydrazine Sulphate


Hydrazine sulphate (or sulfate, in US spelling) is a commonly used, inexpensive industrial compound. Biologically, it inhibits a particular liver and kidney enzyme (a monoamine oxidase or MAO), thereby preventing cancer cells from obtaining glucose. This has been shown to inhibit the cachexia (wasting), which is the immediate cause of death in over 70% of cancer cases. In a smaller number of cases, there is also some tumour regression. This enables some patients to overcome their cancer or to live with it. This has been demonstrated in several clinical trials.

Research began in 1968 with an article suggesting that cachexia could be reduced by targeting a particular liver and kidney enzyme. Dr Joseph Gold of the Syracuse Cancer Research Institute of New York, who has pioneered the use of hydrazine sulphate as a cancer treatment, began testing rodents with hydrazine sulphate, getting rapid and positive results. The compound was then tested on human beings, with mixed results.

Like most cancer treatments, mainstream or complementary, hydrazine sulphate does not always work. There is also a long list of foods with which it interacts badly, and it should only be taken under medical supervision. Like other MAO inhibitors, it is incompatible with barbiturates, tranquilizers, alcohol and other depressants of the central nervous system. Foods high in the amino acid, tyramine, such as mature cheeses and fermented foods should also be avoided.

Hydrazine sulphate has been the focus of considerable controversy in the cancer industry. Mainstream organizations refer to trials sponsored by the National Cancer Institute in the mid-1990s, which showed no benefit from its use. Critics have observed that these trials did not follow the correct procedures, since 94% of the patients were given tranquilizers, and were permitted the use of alcohol and barbiturates.

Annie Appleseed Project – An excellent introduction and overview, with some details of dosage, and which foods to avoid.

Diagnose Me – A useful overview.

Day Industries
Hydrazine Sulfate: The Real Story. A narrative overview.

Syracuse Cancer Research Institute – The charitable organization where Dr Joseph Gold works.

The Truth about Hydrazine Sulfate – Dr Joseph Gold tells his side of the story.

National Cancer Institute – A summary of hydrazine sulphate trials and other information from the viewpoint of the NCI.

National Institute of Health – A summary of the events in the political and trial history of hydrazine sulphate.

The Moss Reports – A review of trial data from before publication of results from the NCI-sponsored trials.

Dr Burton Goldberg – “Holding the National Cancer Institute Accountable for Cancer Deaths.” An overview of some of the politics surrounding hydrazine sulphate.

Nu-gen Nutrition – A source of hydazine sulphate from a US supplier of complementary cancer treatments.


Caesium Chloride– High pH Therapy


Caesium or cesium (US spelling) chloride is associated with the high pH (alkalinizing) therapeutic approach to cancer treatment. The theory that cancer cells are more susceptible than normal cells to high pH originated with the observation that certain areas of the world with a lower risk of cancer also had a higher soil concentration of alkali metals (especially potassium, caesium, and rubidium).

Researchers back in the 1920s first suggested caesium might be a useful anti-tumour agent. However, further studies in the 1930s showed no evidence for this. The high pH therapy for cancer was first advanced during the 1980s by Keith Brewer PhD, who published numerous papers and articles concerning the treatment, together with suggestions for further research. Dr Brewer was a physicist who felt that many of the findings of physics were relevant to biology, especially the physics of the cell membrane. He arrived at his therapeutic approach after considerable experimentation on cell membranes. Animal research studies confirming his theory, funded by Dr Brewer, were undertaken by Dr Marilyn Tufte of the Department of Biology at the University of Wisconsin at Platteville. A small number of uncontrolled human trials conducted by various physicians, especially Dr H.A. Nieper in Hannover, Germany and Dr H.E. Sartori in Washington, DC, also showed significant positive results. As well as loss of pain within 12 to 24 hours, the treatment also resulted in rapid shrinkage of the tumour mass. However, Nieper and Sartori were also using vitamin B17, which in itself is regarded as a significant cancer treatment, so their results are not conclusive.

High pH therapy using caesium chloride therapy is usually given to patients with advanced metastatic cancer, for whom standard medicine can do no more. However, due to lack of sufficient research, there is no agreed dosage or treatment protocol. Generally, up to 6 to 9 gms per day (or sometimes more) of caesium chloride is administered in liquid form along with vitamins A and C, together with zinc and selenium supplements, which enhance the cellular uptake of caesium. Keith Brewer observes that there is some evidence that vitamin B17 is a more effective enhancer than vitamins A and C, but the net effect on tumours may be due to the direct effect of the B17 itself. Since caesium chloride pills or capsules can cause perforation of the stomach wall, it is safer to take it in liquid form immediately after a meal.

Mainstream critics of the therapy claim that scientific studies provide little evidence that cancer cells are any more sensitive than normal cells to an elevated pH. Whether or not this is true requires further research. Nevertheless, this does not invalidate the positive empirical results, however limited they may be.

In the doses mentioned, the most common side effects of caesium chloride therapy are nausea and diarrhoea. Nieper claims that in his experience nausea is reduced by taking caesium chloride in a solution of sorbitol. Neurological symptoms such as numbness in the extremities (probably due to potassium depletion) and irregular heart beat have also been reported. Since caesium competes with potassium, which is essential for normal cell function, it is essential for patients to follow caesium chloride treatment under the care of a qualified doctor, who can monitor potassium levels and other key markers, such as calcium and uric acid.

Caesium chloride should be distinguished from the radioactive isotope, caesium 137, which is used in some forms of radiation therapy.

Phamacology Biochemistry and Behavior – “The High pH Therapy for Cancer: Tests on Mice and Humans.” A seminal paper by Keith Brewer concerning his ideas and experimentation, together with information concerning areas of the world with low incidence of cancer and high levels of caesium and rubidium.

Cesium Cancer Therapy – A general and fairly neutral overview.

Dr James Howenstine – “Use of Cesium Chloride to Cure Malignancies.” A useful overview, with therapeutic details.

Cancer Tutor – “The Cesium Chloride / DMSO Protocol for Treating Cancer.” Contains some useful advice and links. This site also gives details of Robert Barefoot's cesium chloride protocol.

Dr Sartori – Articles published by one of the leading promoters of Keith Brewer's work.

Life Science University Medical Center – “Cesium Therapy in Cancer Patients.” Dr Sartori's report on results with 50 patients.

American Cancer Society – The cautious, mainstream viewpoint.


Zeolite Clinoptilolite – Natural Cellular Defense


Zeolites are minerals, comprising a group of around 30 crystalline aluminosilicates, found worldwide as major constituents of volcanic sediments, formed as a result of the chemical interaction of volcanic ash and sea water.

One of the four known fibrous forms of zeolite, clinoptilolite, is currently the subject of an high-pressure multi-level marketing program under the name of Natural Cellular Defense (NCD), also called Liquid Zeolite. In fact, when searching the internet for information on NCD, the majority of sites focus more on the money you can make from selling NCD than on its supposed health benefits. On the basis of a very small number of cell culture and animal studies, together with largely unverifiable anecdotal evidence, the US manufacturer (Waiora) claims that NCD supports a healthy immune system; helps remove heavy metals, toxins and other substances from the body; helps balance bodily pH levels; is 100% percent natural and non-toxic; and is safe for long-term use. It should be noted that although the original product patent was for a cancer drug, the company ultimately decided to market it as a dietary supplement, no doubt because of the more stringent legislation governing claims that can be made for drugs as opposed to dietary supplements.

Clinoptilolite has been the subject of a large number of studies, most of which relate to its use in industrial processes, especially as regards its established ability to bind to toxic metals. In a few laboratory studies on various cancer cell cultures and tumour-bearing animals, zeolite clinoptilolite prolonged life and in some cases reduced tumour size. In one study, the mechanism was thought to be through ‘lipid peroxidation'. Scientific studies of mice and dogs showed improvement in their overall health, life extension, and reduction in tumour sizes. Local application to dogs' skin cancers also exhibited a reduction in both tumour formation and growth. Other animal studies have revealed no short term toxic effects from the treatment.

Some of the websites mention a small clinical trial by LifeLink Pharmaceuticals, in which a significant percentage of terminal cancer patients went into remission after taking NCD. The report of this trial is as yet unpublished, and may remain so. Apparently, although patients who had started taking NCD were stage 3 and 4 cancer patients for whom standard medicine could do little more, there was no control regarding other therapeutic techniques or substances that the patients were using. Positive results could not therefore be attributed to NCD alone or, indeed, at all.

Clinoptilolite by itself is an insoluble rock crystal. The manufacturer therefore uses a micronizing process by which the particles are made so small (a few micrometres) that they can be absorbed into the body by the intestines.

It is important to check the source and contents of any zeolite sold as a dietary supplement. One such product, Vulkansandkuren (now unavailable, at least on the internet), promoted for body detoxification, actually contained arsenic, lead, aluminium and dioxins, all of which are themselves toxic. Wiaora claim that all traces of heavy metals are removed during their patented micronizing process.

Some zeolites, such as asbestos, are well known for their carcinogenicity when inhaled. In a few parts of the world, the fibrous zeolite, erionite, is present in the environment. In remote Anatolian villages (in Turkey), a high incidence of lung cancer and mesothelioma (cancer of the lining of the lung, abdominal cavity and heart, more commonly associated with asbestos exposure) has been attributed to the presence of erionite in the soil, road dust, and local building materials. These places also have a higher than average incidence of other cancers. Critics have pointed to this potential long-term problem with the use of NCD. The manufacturer counters this by pointing to a 1993 study on rats which concluded that zeolite clinoptilolite has no carcinogenic activity. Moreover, zeolite clinoptilolite has been given GRAS (generally regarded as safe) status by the US Federal Drug Administration (FDA).

As is common with products where the data is both limited, preliminary, and open to interpretation, Natural Cellular Defense is the subject of considerable – often emotive – internet discussion. Selling NCD through multi-level marketing also creates an army of highly motivated sales people, many of whom may have little real understanding of the product, and whose enthusiasm and financial motivation can rapidly distort the available data.

Liquid Zeolite – A comprehensive, information resource site.

Pacific Rim Marketing – A marketing and Liquid Zeolite information site, with testimonials, details of the original patent, links to most of the relevant research studies, and so on.

Cellular Detox – A useful collection of NCD product brochures, together with some scientific papers concerning zeolite as both an anti-cancer agent, animal food supplement and industrial cleansing product.

Jonathan Campbell – A natural health consultant gives his reasons for not using zeolite.

News Target – Mike Adams' long and emotively argued justification in favour of NCD, including the positive recommendation of Gabriel Cousens, and a response to Joseph Campbell's article, which includes a letter from Rik Deitsch, chairman of Waiora's scientific advisory board.

Tree of Life Rejuvenation Center – A glowing endorsement of NCD published here by a US vendor, which largely consists of the enthusiastic pro-NCD article by Gabriel Cousens. Cousens is well known in the natural health world and is also a director of the Tree of Life Rejuvenaton Center. This site also provides guidelines for using NCD, followed immediately by a larger section on how to sign up as a distributor.

Waiora – The US manufacturer's somewhat sparse product information, with no links or specific references to any of the scientific research to which they refer. They also run a separate site devoted to the high-pressure marketing of NCD distributorships.

Squidoo – A site promoting the purchase of a shareholding in this “exploding company” (Waiora). In their words, “Never before in history have you been presented with such a powerful opportunity.... Now is the time to act! Every moment counts! Don't let this pass you by!” This exemplifies the fact that there is more internet hype concerning making money from NCD than there is convincing scientific data of its actual efficacy in human situations.

Anticancer Research – “Anticancer and antioxidative effects of micronized zeolite clinoptilolite.”

Journal of Molecular Medicine – “Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.”

Polish Journal of Occupational Medicine and Environmental Health – “Study on carcinogenicity of clinoptilolite type zeolite in Wistar rats.” A study showing the lack of any carcinogenic effect.

PubMed – Research studies on the properties of the zeolite, clinoptilolite, mostly in non-health-related scenarios. Search for ‘clinoptilolite' on this site.

American Cancer Society – Physical carcinogens. A scientific review of some of the known carcinogens, also containing some information on zeolites.


Copyright John Davidson, 2006, 2008

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